She entered films in 2004 debuted in Phir Milenge, the film was based on the AIDS subject. But she got fame by the movie Anand, the multiple-award winning film.

Kamalinee Mukherjee Filmography:
2004 Phir Milenge (Hindi film), Anand (Telugu film). 2005 Meenakshi (Telugu film). 2006 Godavari (Telugu film), Vettaiyyaadu Vilaiyaadu (Tamil film). 2007 Classmates, Pellaindi Kaani (Telugu films). 2008 Brahmanandam Drama Company, Gamyam, Jalsa (Telugu films). 2009 Savaari (Kannada film), Kadhalna Summa illai, Idam Valam (Tamil film), Gopi Gopika Godavari (Telugu film).